MTHFR & Methylation
Your MTHFR variant doesn't define you. Environment, nutrition, and lifestyle determine whether these genes help or hurt. The supplement industry has overcomplicated what should be simple.
MTHFR for Beginners
A clear introduction to MTHFR variants—what they actually mean, why they matter, and why the supplement industry has it mostly wrong.
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MTHFR Is Not What You Think
Why pushing methylation can backfire. The overlooked problem of overmethylation from 30,000+ patient data.
Genetic Destiny?
50-70% of methylation variation responds to environment, not genes. Your MTHFR status isn't fixed.
MTHFR & COMT
How these two genes interact to affect histamine, dopamine, estrogen, and your stress response.
The Folic Acid Problem
Folic Acid Conspiracy
Why we fortify food with synthetic folic acid despite knowing it causes problems.
Folic Acid Is Slow
Not just MTHFR—everyone processes synthetic folic acid poorly. The research is clear.
Infertility & Nutrition
The connection between folate status, methylation, and reproductive health.
Pregnancy & Histamines
Why pregnancy changes methylation and histamine tolerance dramatically.
Methylation Cofactors
Glutathione-B12 Connection
Why B12 and glutathione are linked, and why you need both for proper methylation.
Rebuilding Glutathione
The master antioxidant that supports methylation and detoxification.
Lithium Exposes Megadosing
How trace lithium reveals the problems with high-dose B vitamin protocols.
Magnesium Timing
Magnesium is required for 300+ enzymes including methylation. Timing matters.
Related Topics
Methylation connects to many other systems: