ConditionMusculoskeletal

Osteoarthritis

Wear and tear on joints—or is it? Osteoarthritis involves cartilage breakdown, but inflammation plays a bigger role than once thought. Not just aging—obesity, injury, and genetics matter. Often slowed with the right interventions.

Osteoarthritis progression and treatment
32M+
US Adults
Knees
Most Common
50+
Age Onset
Modifiable
Progression

What Happens in OA

Cartilage Breakdown

Protective cartilage wears away. Bones rub together. Pain and stiffness result.

Bone Changes

Bone spurs (osteophytes) form. Bones thicken. Joint deformity can occur.

Inflammation

Synovium becomes inflamed. Drives progression. Not just mechanical wear.

Muscle Weakness

Surrounding muscles weaken. Less joint support. Accelerates damage.

Risk Factors

Modifiable

  • Obesity: Each pound = 4lbs knee pressure
  • Joint injury: Increases OA risk 3-4x
  • Overuse: Repetitive occupational stress
  • Muscle weakness: Less joint protection
  • Inflammation: Metabolic syndrome link

Non-Modifiable

  • Age: Risk increases with age
  • Sex: More common in women after 50
  • Genetics: Family history matters
  • Joint alignment: Bowlegged/knock-kneed

Supportive Nutrients

Glucosamine

Cartilage building block. Mixed evidence but many benefit. 1500mg daily. Sulfate form.

Chondroitin

Cartilage component. Often combined with glucosamine. 800-1200mg daily.

Collagen

Type II for joints. Hydrolyzed for absorption. 10g daily studied. UC-II different mechanism.

Omega-3 Fatty Acids

Reduces joint inflammation. 2-3g EPA+DHA daily. Helps pain and function.

Vitamin C

Essential for collagen synthesis. Antioxidant. 500-1000mg daily.

MSM

Sulfur for connective tissue. Anti-inflammatory. 3-6g daily.

SAM-e

Comparable to NSAIDs in studies. Supports cartilage. 400-1200mg daily.

Curcumin

Potent anti-inflammatory. Enhanced absorption forms. 500-1000mg daily.

Boswellia

Anti-inflammatory herb. AKBA extract most studied. 100-250mg daily.

Exercise & Movement

Low-Impact Aerobic

Walking, swimming, cycling. 150 min/week. Maintains joint health.

Strength Training

Builds muscle support. Reduces joint load. 2-3x weekly.

Range of Motion

Prevents stiffness. Gentle stretching. Daily is ideal.

Aquatic Exercise

Water supports joints. Allows more activity. Warm water soothing.

Tai Chi/Yoga

Balance and flexibility. Mind-body benefits. Proven OA benefits.

Physical Therapy

Personalized program. Correct movement patterns. Highly recommended.

Treatment Options

Weight Loss

Most effective intervention. 10% loss = 50% symptom reduction. Reduces inflammation too.

Topical NSAIDs

Diclofenac gel. Local effect. Less GI side effects. Hands/knees especially.

Injections

Corticosteroids (temporary). Hyaluronic acid (lubrication). PRP (regenerative).

Bracing

Unloader braces for knee OA. Shifts load. Can delay surgery.

Joint Replacement

When conservative fails. Knee/hip most common. 20+ year lifespan.

Heat/Cold Therapy

Heat for stiffness. Ice for acute pain. Simple and effective.

Osteoarthritis Discussion